We believe evidence is a duty, not a chore

Our digital treatments aren’t just based on science: They’ve been proven effective in gold-standard clinical trials.

Setting the standard for rigorous clinical evidence

We believe digital treatments must be put to the test as rigorously as traditional medicine. People’s mental health depends on it. That belief not only fuels our commitment to clinical evidence — it also drives our efforts to make research more equitable for underserved populations.

75

Publications

14

Randomised controlled trials (RCTs)

28k+

Study participants

4

Clinical guideline citations1-4

Sleepio helped 76% of patients achieve clinical improvement in insomnia

In the world’s first placebo-controlled trial for a digital treatment, Sleepio was shown to be significantly more effective than the placebo. After six weeks, 76% of Sleepio users achieved clinical improvement in insomnia.5

Graph depicting the % of patients achieving healthy sleep using Sleepio versus a placebo and versus "treatment as usual."

Daylight helped 71% of patients achieve clinical improvement in anxiety

In a landmark study, Daylight demonstrated significantly greater reductions in symptoms of clinical anxiety than the control condition. After 10 weeks, 71% of Daylight users moved from clinical to non-clinical levels of anxiety, as compared to 33% of those in the control group.6

Graph depicting levels of anxiety (measured with the GAD-7) from Week 0 to Week 10 for both Daylight users and a waitlist control.

Featured studies

The effects of dCBT for insomnia on cognitive function

Kyle et al. (2020)/SLEEP
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Efficacy of dCBT for moderate-to-severe symptoms of generalized anxiety disorder

Carl et al. (2020)/Depression & Anxiety
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A randomized controlled trial of dCBT for insomnia in pregnant women

Kalmbach et al. (2020)/Sleep Medicine
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Efficacy of dCBT for the treatment of insomnia symptoms among pregnant women

Felder et al. (2020)/JAMA Psychiatry
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A pilot RCT for dCBT for sub-threshold insomnia

Denis et al. (2019)/Sleep Med
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RCT on impact of dCBT for insomnia on health, wellbeing, and quality of life

Espie et al. (2018)/JAMA Psychiatry
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Efficacy of dCBT for insomnia to improve depression across demographic groups

Cheng et al. (2018)/Psychological Medicine
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The effects of improving sleep on mental health (OASIS)

Freeman et al. (2017)/Lancet Psychiatry
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Sleep to lower elevated blood pressure (SLEPT)

McGrath et al. (2017)/American Journal of Hypertension
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Helping employees sleep well: effects of CBT for insomnia on work outcomes

Barnes et al. (2017)/Journal of Applied Psychology
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Sleep and productivity benefits of digital CBTi

Bostock et al. (2016)/JOEM
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The anxiolytic effects of cognitive behavior therapy for insomnia

Pillai et al. (2015)/Journal of Sleep Medicine Disorders
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RCT of placebo controlled dCBT for chronic insomnia disorder

Espie et al. (2012)/SLEEP
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1. Qaseem, A., Kansagara, D., Forciea, M. A., Cooke, M., & Denberg, T. D. (2016). Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians. Annals of Internal Medicine, 165(2), 125-133.
2. Riemann, D., Baglioni, C., Bassetti, C., Bjorvatn, B., Dolenc Groselj, L., Ellis, J. G., … & Spiegelhalder, K. (2017). European guideline for the diagnosis and treatment of insomnia. Journal of Sleep Research, 26(6), 675-700.
3. Wilson, S., Anderson, K., Baldwin, D., Dijk, D. J., Espie, A., Espie, C., … & Sharpley, A. (2019). British Association for Psychopharmacology consensus statement on evidence-based treatment of insomnia, parasomnias and circadian rhythm disorders: an update. Journal of Psychopharmacology, 33(8), 923-947.
4. King’s Technology Evaluation Centre. (2017, November 9). Overview: Health app: SLEEPIO for adults with poor Sleep: Advice. NICE. https://www.nice.org.uk/advice/mib129.
5. Carl, J. R., Miller, C. B., Henry, A. L., Davis, M. L., Stott, R., Smits, J. A., … & Espie, C. A. (2020). Efficacy of digital cognitive behavioral therapy for moderate‐to‐severe symptoms of generalized anxiety disorder: A randomized controlled trial. Depression and Anxiety, 37(12), 1168-1178.
6. Espie, C. A., Kyle, S. D., Williams, C., Ong, J. C., Douglas, N. J., Hames, P., & Brown, J. S. (2012). A randomized, placebo-controlled trial of online cognitive behavioral therapy for chronic insomnia disorder delivered via an automated media-rich web application. Sleep, 35(6), 769-781.